Basic Theophylline Information

• INN (International Nonproprietary Name): Theophylline • Brand names available in United Kingdom: Uniphyllin, Theolair • ATC Code: R03DA01 • Forms & dosages: Tablets (100 mg, 200 mg), Injection (10 mg/ml), Syrup (80 mg/15 ml) • Manufacturers in United Kingdom: Teva, Mylan • Registration status in United Kingdom: Prescription only • OTC / Rx classification: Prescription (Rx)

Everyday Use & Best Practices

Morning Vs Evening Dosing

Determining the optimal time for taking theophylline hinges on one’s daily routine and sleep habits. Many patients find it beneficial to take theophylline in the morning, especially if their activities are intensified during the day. This timing can aid in managing symptoms of asthma or COPD when they are most active.

Conversely, for those who work night shifts or have irregular hours, evening dosing might be advocated. Consistency in timing is paramount; taking theophylline at the same time every day helps maintain stable blood levels and enhances effectiveness.

Factors to consider include:

• Typical daily activities
• Sleep patterns and hours
• Potential for side effects like insomnia, which may influence the timing of doses

By aligning theophylline dosing with personal schedules, patients can maximise the medication's benefits while minimising disruptions in their daily lives.

Taking With Or Without Meals (UK Diet Habits)

When it comes to the absorption and efficacy of theophylline, the role of food cannot be overlooked. Ideally, theophylline can be taken with or without food; however, meals high in fat might influence the rate of absorption, leading to either delayed or altered therapeutic effects.

Considering typical dietary habits in the UK, many may prefer taking their medication with breakfast or lunch when meals are regularly consumed. If a patient tends to have a snack-heavy diet, planning doses around these meal times may also prove effective.

Key points to remember include:

• Fatty meals could slow down absorption, so it might be wise to avoid them close to dosing times.
• Patients uncertain about the ideal timing with their meals are encouraged to consult with healthcare providers or pharmacists for personalised advice.
• Avoiding theophylline intake with caffeine-containing foods or drinks (like chocolate, coffee, or tea) can mitigate a risk of increased side effects, as caffeine may enhance its stimulant effects.

Being mindful of how and when to take theophylline, alongside understanding its interactions with common UK dietary habits, can lead to more controlled management of respiratory symptoms and an overall improved quality of life.

Safety Priorities

Who should avoid it (MHRA warnings)

The MHRA emphasizes caution with theophylline usage, particularly for patients with specific health conditions. Certain individuals must avoid this medication altogether. Those with known hypersensitivity to theophylline or any of its components should refrain from using it. Additionally, patients with severe hepatic impairment should not take theophylline as it may exacerbate liver-related issues. Conditions such as cirrhosis can lead to elevated theophylline levels in the blood, increasing the risk of toxicity. Other relative contraindications include individuals with chronic alcohol use or those who have experienced severe adverse reactions in the past.

Activities to limit (driving, work safety)

Engaging in activities that demand full attention, such as driving or operating heavy machinery, should be approached with caution when using theophylline. Some patients may experience side effects such as dizziness, palpitations, or even nausea. These effects can significantly impact concentration and coordination. Therefore, before participating in such activities, individuals using theophylline must assess their tolerance and side effects. It's advisable to have a discussion with a healthcare provider about any worrying symptoms to determine the safest course of action moving forward.

Dosage & Adjustments

General regimen (NHS guidance)

Many folks wonder about the right dosage for theophylline, especially when it comes to managing conditions like asthma or COPD. The NHS suggests that adults typically start with a specific dosage, often ranging from 300 mg to 600 mg daily, divided into two or three doses. But that's just a guideline; individual requirements could vary significantly.

For children, dosing is usually calculated based on their weight, typically around 10–15 mg/kg per day. It’s crucial to regularly monitor blood levels because theophylline has a narrow therapeutic index, meaning too high or too low levels can lead to serious consequences. Always consult with healthcare professionals to tailor the regimen to individual needs and ensure safety.

Special cases (elderly, comorbidities)

When it comes to the elderly or those with chronic conditions like COPD or asthma, medication adjustments are vital. Age and pre-existing conditions can impact the way the body processes theophylline. For elderly patients, lower starting doses are often recommended, along with close monitoring for side effects.

For those with comorbidities, such as liver or kidney issues, dose modifications are usually necessary. Patients taking other medications that interact with theophylline, like erythromycin or cimetidine, may also require adjustments. It's essential for healthcare providers to tailor the dosing plan, ensuring that intended benefits are achieved while minimising the risk of toxicity.

Delivery Information

City	Region	Delivery Time
London	London	5–7 days
Birmingham	West Midlands	5–7 days
Manchester	Greater Manchester	5–7 days
Leeds	West Yorkshire	5–7 days
Glasgow	Scotland	5–7 days
Sheffield	South Yorkshire	5–7 days
Bristol	South West	5–7 days
Newcastle upon Tyne	Tyne and Wear	5–7 days
Cardiff	Wales	5–7 days
Coventry	West Midlands	5–9 days
Brighton	East Sussex	5–9 days
Nottingham	East Midlands	5–9 days
Derby	East Midlands	5–9 days
Portsmouth	Hampshire	5–9 days