Basic Keftab Information

International Nonproprietary Name (INN)

Cephalexin (INN)

Brand Names Available in United Kingdom

ATC Code

J01DB01: First-generation cephalosporin, antibacterial for systemic use[1][2]. Cephalexin is a beta-lactam antibiotic, more resistant to some beta-lactamases than penicillins[4].

Forms & Dosages

• Oral tablets/capsules: 250mg, 500mg, 1g
• Oral suspension/syrup/sachet: 125mg/5mL, 250mg/5mL (for pediatric use)
• No injectable or topical forms widely marketed

Manufacturers in United Kingdom

Main global manufacturers: Sandoz (Novartis), Lupin, Ranbaxy, Glenmark, Pfizer (Upjohn), Teva, Mylan, and various generic pharmaceutical manufacturers.

Registration Status in United Kingdom

• USA (FDA): Approved (Keflex, Keftab)[2]
• EU (EMA): Approved (Keflex, Cefalexin)

OTC / Rx Classification

Prescription-only (Rx) in nearly all jurisdictions. Not available over the counter (OTC)[1][2].

Everyday Use & Best Practices

Morning Vs Evening Dosing

Having a consistent dosing schedule is crucial for Keftab's optimal effectiveness. Whether it's first thing in the morning or just before settling in for the night, sticking to a routine helps maintain the right level of medication in the body. Generally, morning dosages fit well with most UK daily routines, allowing individuals to take their medication alongside breakfast. Conversely, evening doses can effectively integrate into post-dinner schedules, especially if combined with some bedtime snacks.

Taking With Or Without Meals

Food intake can significantly impact how well Keftab is absorbed. For many, taking Keftab with food can help mitigate potential gastrointestinal discomfort, a common concern with antibiotic use. In the UK, typical meal patterns—such as mid-morning breaks, lunch, and dinner—offer good opportunities for timing doses.

It's often recommended to take Keftab with a meal to enhance absorption and reduce side effects. A light meal, like toast or porridge, can suffice. Ensuring that meals contain a mix of carbohydrates, proteins, and fats is essential, as these components can aid in the efficient absorption of the medication.

When considering UK dietary habits, many people might prefer to take Keftab at breakfast or dinner to align with their usual eating routine. Serious consideration of these factors can lead to improved outcomes and patient satisfaction. For those who are curious about how to buy Keftab, local pharmacies such as Boots, LloydsPharmacy, and Superdrug often stock it, making it relatively easy to obtain.

For further information on Keftab, including its cost and user reviews, patients can consult NHS resources or trusted online platforms.

What’s Inside & How It Works

Ingredients overview

Keftab, known generically as cephalexin, is a first-generation cephalosporin antibiotic. The primary active ingredient, cephalexin, plays a crucial role in its effectiveness against bacterial infections. Each capsule or tablet typically contains either 250mg, 500mg, or 1g of cephalexin. Inactive ingredients may include fillers and binders, such as microcrystalline cellulose, magnesium stearate, and gelatin, depending on the manufacturer. These components ensure the stability and proper delivery of the active ingredient.

Mechanism basics explained simply

Cephalexin works by targeting bacterial cell walls. It inhibits the synthesis of peptidoglycan, a vital component of bacterial cell walls, which leads to cell lysis and death. This makes it particularly effective against gram-positive bacteria, helping to effectively treat a variety of infections, such as those in the skin, respiratory tract, and urinary tract. By stopping bacteria from multiplying, Keftab reduces the severity of the infection and allows the body’s immune system to take over and heal.

Main Indications

Approved uses (MHRA listing)

Keftab is approved by the MHRA for a range of bacterial infections. These include:

• Respiratory tract infections
• Skin infections
• Urinary tract infections (UTIs)
• Bone infections
• Prophylaxis for certain dental procedures

Off-label uses in UK clinics

In UK clinical practice, Keftab is sometimes prescribed off-label for conditions such as sinusitis and certain types of gastroenteritis. Physicians may opt for Keftab when treating infections caused by bacteria that are resistant to other antibiotics, utilising its broad-spectrum efficiency.

Interaction Warnings

Food interactions (alcohol, tea/coffee)

Certain food and drinks can affect the efficacy of Keftab. Alcohol may increase the risk of side effects like gastrointestinal discomfort and should ideally be avoided during treatment. Additionally, caffeine-containing products like tea and coffee may cause increased side effects or may affect absorption rates. It's best to maintain a stable diet while taking the medication.

Drug conflicts (MHRA Yellow Card reports)

Interactions with other medications can also occur. For example, probenecid, a medication used to treat gout, may increase cephalexin levels in the blood, enhancing both efficacy and potential toxicity. Other drugs that alter kidney function can influence cephalexin clearance, necessitating careful monitoring during the concurrent use of Keftab.

Latest Evidence & Insights

Recent studies, particularly from 2022 to 2025, have highlighted Keftab's effectiveness in treating uncomplicated bacterial infections. Research indicates that Keftab continues to be a mainstay in first-line therapy for respiratory and skin infections. Observational studies suggest low resistance rates among treated populations, reinforcing its safety and efficacy within the UK context. Clinical trials have also shown minimal adverse effects when prescribed correctly, further supporting its utilitarian role in modern medicinal practices.

Alternative Choices

When considering alternatives to Keftab, the NHS provides a range of effective antibiotics. For instance:

• Cefadroxil
• Amoxicillin
• Ampicillin
• Azithromycin,

These medications may offer similar benefits with varying side effects and costs. In many cases, amoxicillin is less expensive and suitable for respiratory and ear infections, while cefadroxil may provide broader spectrum coverage. When prescribed, cost and side effects should inform the best choice for each patient, ensuring optimal outcomes.

Regulation Snapshot

The regulatory landscape for Keftab, which contains the active ingredient cephalexin, is quite structured in the United Kingdom. Currently, it holds a prescription-only status in nearly all countries, including the UK, meaning it can't be purchased over the counter. The UK Medicines and Healthcare products Regulatory Agency (MHRA) has approved Keftab for use, ensuring its safety and efficacy for treating various bacterial infections.

Within the NHS framework, Keftab is prescribed under specific clinical guidelines. Generally, it falls under the antibiotic category for treating respiratory tract infections, skin infections, and urinary tract infections. As part of responsible prescribing practices, clinicians are advised to confirm that patients complete their full course of antibiotics to combat antibiotic resistance. Keftab's availability through NHS services provides patients access to effective treatment options following a healthcare professional's assessment.

FAQ Section

Many patients have questions when prescribed Keftab. Here are some common queries:

• Can I take Keftab with other medications?
  Consult the pharmacist or doctor, as drug interactions may affect the effectiveness of Keftab or cause side effects.
• What should I do if I miss a dose?
  If you forget a dose, take it as soon as you remember. However, skip it if it’s nearly time for the next one. Never double up.
• Are there any common side effects?
  Some individuals might experience mild side effects like nausea, stomach discomfort, or diarrhea. It’s crucial to monitor your reaction and inform your healthcare provider of any significant changes.
• How can I store Keftab properly?
  Store Keftab at room temperature, away from excess moisture and heat. If it's a suspension, refrigerate once reconstituted and discard after 14 days.

Guidelines for Proper Use

UK pharmacist counselling style

Patients can expect supportive advice in a friendly manner from pharmacists. They may discuss:

• Dosage instructions and the importance of adhering to the prescribed course.
• Possible side effects and when to seek medical advice.
• Interactions with other medications and lifestyle considerations.

Pharmacists are generally available for follow-up questions, ensuring patients feel informed and supported throughout their treatment.

NHS patient support advice

The NHS offers a range of resources for individuals taking Keftab. Patients can contact:

• The NHS helpline for inquiries about medications and health concerns.
• NHS website for educational materials related to antibiotics and infection management.
• Your local GP can also provide detailed guidance specific to treatment plans.

These resources ensure patients can obtain information and assistance at any stage of their treatment journey.