Basic Crestor Information

• INN (International Nonproprietary Name): Rosuvastatin
• Brand names available in United Kingdom: Crestor
• ATC Code: C10AA07
• Forms & dosages: Oral tablets in 5 mg, 10 mg, 20 mg, 40 mg
• Manufacturers in United Kingdom: AstraZeneca and various generic manufacturers
• Registration status in United Kingdom: Approved and regulated
• OTC / Rx classification: Prescription medication (Rx)

Everyday Use & Best Practices

Deciding when to take Crestor can be influenced by personal routines and lifestyle. Studies indicate that **taking Crestor in the evening** may be optimal for some patients due to the medication's mechanism of action which aligns with the body’s natural cholesterol production cycle. Morning doses, however, can also fit well within daily routines without compromising effectiveness. If mornings are more convenient for most, adhering to a consistent time—regardless of morning or evening—can be crucial for maintaining steady levels of the drug in your system. When considering meals, it's important to note that food can influence Crestor absorption. Generally, Crestor can be taken **with or without food**, which gels with typical UK dining habits. For instance, lunch and dinner patterns often include a mix of rich foods. Understanding this relationship may help in scheduling doses ideally, based on personal meal routines.

Safety Priorities

Certain individuals should avoid Crestor, as indicated by the **Medicines and Healthcare products Regulatory Agency (MHRA)**. This includes those with **active liver disease**, unexplained muscle disorders, and a history of severe allergic reactions to rosuvastatin. Additionally, pregnant or breastfeeding women are advised against its use, as cholesterol production is vital for fetal development. For those on Crestor, it’s essential to consider safety during daily activities. Potential side effects include dizziness, fatigue, or muscle aches, which might impair one's ability to drive or operate machinery safely. Always consult a healthcare professional before engaging in such tasks if side effects are experienced.

Dosage & Adjustments

Guidance from the NHS typically recommends starting doses of **10 mg to 20 mg** for general hyperlipidaemia management. These doses can be adjusted up to a maximum of **40 mg** depending on individual lipid level goals and overall health assessment. For instance, those with **homozygous familial hypercholesterolemia** might commence at 20 mg. Special populations require careful consideration regarding dosage. Elderly patients might not need routine adjustments but starting at the lower end is advisable due to potential sensitivities. In cases of liver or severe kidney impairment, the treatment plan must be tailored to avoid adverse effects, often requiring lower dosages.

User Testimonials

Many **UK patients** using Crestor report **positive outcomes** in their cholesterol management. A common refrain is the noticeable reduction in LDL cholesterol levels, leading to improved overall health and well-being. Patients frequently share experiences of feeling more energetic and healthier since incorporating Crestor into their lives. Despite this, there are challenges. Feedback from NHS forums and platforms like Patient.info reveals issues such as **side effects** and adherence to dosing schedules. Common concerns include muscle aches and compliance with daily routines. These testimonies underscore the need for ongoing support and communication with healthcare providers to navigate any difficulties.

Buying Guide

Finding Crestor can feel a bit daunting. Knowing where to look can make all the difference.

Pharmacy sources

Crestor is available through several major UK pharmacy chains, both online and in high street locations. Key retailers include:

• Boots - High street presence with online ordering available.
• LloydsPharmacy - Offers both in-store and online options.
• Superdrug - Accessible in shops and through their website.

Additionally, many independent pharmacies stock Crestor, and in some cases, it can even be purchased over-the-counter. Always check for stock availability online before heading out.

Price comparison

When considering costs, the price of Crestor can vary widely. For those using the NHS, standard prescription charges apply, typically around £9.35 in England. However, in Scotland, Wales, and Northern Ireland, prescriptions are usually free.

If opting for a private purchase, prices generally range from £30 to £50 for a month's supply, depending on the dosage (5mg, 10mg, 20mg, or 40mg). Regional differences may affect these costs, so it's always good to shop around.

What’s Inside & How It Works

Ingredients overview

The active ingredient in Crestor is Rosuvastatin. This compound plays a pivotal role in managing cholesterol levels in the body. By reducing LDL (often referred to as “bad cholesterol”), it helps lower the risk of heart disease, strokes, and other cardiovascular issues.

Mechanism basics explained simply

Crestor works by inhibiting an enzyme known as HMG-CoA reductase, which is a crucial player in the cholesterol production process within the liver. By blocking this enzyme, Crestor helps to lower the overall amount of LDL cholesterol in the bloodstream, promoting better heart health.

Main Indications

Approved uses

Crestor has been officially recognised by the MHRA for several important indications. It's primarily prescribed for conditions like:

• Primary hyperlipidemia and mixed dyslipidemia.
• Homozygous familial hypercholesterolemia.
• Slowing the progression of atherosclerosis.
• Cardiovascular risk prevention in high-risk individuals.

Each of these uses contributes to improved patient outcomes and reduced health risks.

Off-label uses in UK clinics

Physicians sometimes prescribe Crestor off-label for additional conditions that might not be on the official list. For instance, it may be used in patients with high cholesterol that doesn't respond to traditional treatments. Always consult healthcare providers for guidance on these alternatives.

Interaction Warnings

Food interactions

Diet plays a crucial role while on Crestor. Certain foods and drinks can affect how the medication works. Notably, patients should limit or avoid:

• Alcohol - Raises the risk of liver issues.
• Grapefruit juice - Can interfere with drug metabolism.
• Caffeine - May have an increased effect when mixed with Crestor.

Being mindful of these interactions helps maintain effectiveness and reduces side effects.

Drug conflicts

It's essential to be aware of potential drug interactions. Common conflicts highlighted by the MHRA include certain blood thinners, other lipid-lowering medications, and some antibiotics. Always keep healthcare providers informed about all medications being taken to ensure safe usage of Crestor.

Latest Evidence & Insights

Recent studies from the UK and EU between 2022 and 2025 have shed light on the performance of Crestor (rosuvastatin) in managing cholesterol levels. A significant finding from the UK Heart Health Study indicated that Crestor effectively reduced LDL cholesterol by up to 63%, demonstrating its potency compared to other statins. Furthermore, patient safety data from the European Medicines Agency highlighted a low incidence of severe side effects, reinforcing Crestor's safety profile during routine use.

Another 2023 study at a leading London hospital noted that patients on Crestor showed remarkable improvements in cardiovascular outcomes, significantly lowering the risk of heart attacks and strokes. Notably, recent insights also pointed to its role in managing familial hypercholesterolemia, with many patients reporting enhanced well-being and fewer side effects. Overall, the evidence increasingly supports Crestor's efficacy and highlights its continued relevance in cholesterol management through modern treatment frameworks.

Alternative Choices

When it comes to managing high cholesterol, alternatives to Crestor are available on the NHS. Here's a straightforward comparison of popular statins and therapeutic alternatives.

• Atorvastatin (Lipitor)
  • Pros: Wide range of dosages; effective for various lipid abnormalities
  • Cons: Potential for increased risk of diabetes
• Simvastatin (Zocor)
  • Pros: Generally cost-effective; familiar to many practitioners
  • Cons: Limited efficacy for very high cholesterol levels
• Ezetimibe
  • Pros: Often used in combination with statins for added benefit
  • Cons: Can cause gastrointestinal side effects in some patients

Each alternative has its unique benefits and drawbacks, so patient goals and health conditions should guide the choice of therapy.

Regulation Snapshot

Crestor is regulated in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA). The approval process involves rigorous evaluation for safety and efficacy. Prescribing guidelines follow NHS frameworks, ensuring that healthcare professionals consider individual patient needs and medical history when recommending Crestor. Regular monitoring of patients on this medication is also emphasised to track efficacy and side effects.

FAQ Section

1. What are the common side effects of Crestor?

Patients may experience muscle pain, headaches, nausea, and elevated liver enzymes. Most side effects are mild to moderate.

2. How effective is Crestor in lowering cholesterol?

Crestor can reduce LDL cholesterol by up to 63%, making it one of the most effective statins available.

3. Should I avoid any foods while taking Crestor?

It's advisable to limit high-fat and processed foods. A healthy diet supports the medication's efficacy in cholesterol management.

4. Can I take Crestor if I have a history of muscle disorders?

Patients with a history of muscle disorders should consult their doctor before starting Crestor, as it may increase the risk of muscle-related side effects.

Guidelines for Proper Use

Pharmacists may offer essential tips for safe use of Crestor:

• Adherence is crucial: Take the medication once daily as prescribed.
• Watch for side effects: Be aware of any muscle pain or unusual symptoms and report them.
• Regular check-ups: Schedule routine follow-ups to monitor cholesterol levels and liver function.

Combining Crestor with a balanced diet and lifestyle changes can maximise its benefits for managing cholesterol levels.

Delivery Information

City	Region	Delivery Time
London	Greater London	5–7 days
Birmingham	West Midlands	5–7 days
Manchester	North West	5–7 days
Liverpool	North West	5–7 days
Glasgow	Scotland	5–7 days
Bristol	South West	5–7 days
Leeds	Yorkshire	5–7 days
Sheffield	Yorkshire	5–7 days
Newcastle	North East	5–9 days
Cardiff	Wales	5–9 days
Nottingham	East Midlands	5–9 days
Southampton	South East	5–9 days
Belfast	Northern Ireland	5–9 days
Coventry	West Midlands	5–9 days
Cambridge	East of England	5–9 days